High-Throughput MALDI-MS based readout

On-chip characterization of newly synthesized compounds is particularly critical, since most existing analytical techniques are incompatible with synthesis platforms operating at low volume and concentration and a high level of parallelization. In this application note, we demonstrate proof of concept for a rapid workflow for highly sensitive chip based compound characterization down to the attomole range in high-density nanodroplet arrays based on AQUARRAY’s Droplet Microarray technology as a sample support and read-out by Bruker´s rapifleX® MALDI PharmaPulse® high-speed MALDI-TOF MS system.

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Further reading: Bruker rapifleX MALDI-TOF/TOF